Cargando…

Profile of MMP and TIMP Expression in Human Pancreatic Stellate Cells: Regulation by IL-1α and TGFβ and Implications for Migration of Pancreatic Cancer Cells()

Pancreatic ductal adenocarcinoma is characterized by a prominent fibroinflammatory stroma with both tumor-promoting and tumor-suppressive functions. The pancreatic stellate cell (PSC) is the major cellular stromal component and the main producer of extracellular matrix proteins, including collagens,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tjomsland, Vegard, Pomianowska, Eva, Aasrum, Monica, Sandnes, Dagny, Verbeke, Caroline Sophie, Gladhaug, Ivar Prydz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2016
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954934/ https://www.ncbi.nlm.nih.gov/pubmed/27435927 http://dx.doi.org/10.1016/j.neo.2016.06.003

Ejemplares similares

The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration
por: Tjomsland, Vegard, et al.
Publicado: (2016)

Inhibitory effects of prostaglandin E(2) on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma
por: Pomianowska, Ewa, et al.
Publicado: (2014)

Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells
por: Tjomsland, Vegard, et al.
Publicado: (2017)

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells
por: Amrutkar, Manoj, et al.
Publicado: (2019)

Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
por: Lenggenhager, Daniela, et al.
Publicado: (2019)

Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis
por: Amrutkar, Manoj, et al.
Publicado: (2023)

Differential Gemcitabine Sensitivity in Primary Human Pancreatic Cancer Cells and Paired Stellate Cells Is Driven by Heterogenous Drug Uptake and Processing
por: Amrutkar, Manoj, et al.
Publicado: (2020)

Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor
por: Amrutkar, Manoj, et al.
Publicado: (2020)

Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer
por: Amrutkar, Manoj, et al.
Publicado: (2021)

MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor
por: Kuninty, Praneeth R., et al.
Publicado: (2016)

COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
por: Pomianowska, Ewa, et al.
Publicado: (2014)

Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review
por: Haugvik, Sven-Petter, et al.
Publicado: (2012)

Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells
por: Brusevold, Ingvild J, et al.
Publicado: (2014)

IL-1α Expression in Pancreatic Ductal Adenocarcinoma Affects the Tumor Cell Migration and Is Regulated by the p38MAPK Signaling Pathway
por: Tjomsland, Vegard, et al.
Publicado: (2013)

Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms
por: HAUGVIK, SVEN-PETTER, et al.
Publicado: (2014)

Pancreatic Cancer Chemoresistance to Gemcitabine
por: Amrutkar, Manoj, et al.
Publicado: (2017)

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells
por: Sarper, Muge, et al.
Publicado: (2016)

Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis
por: Lachowski, Dariusz, et al.
Publicado: (2019)

Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta
por: Kuźnik-Trocha, Kornelia, et al.
Publicado: (2020)

Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells
por: Li, Yuchuan, et al.
Publicado: (2023)

Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1β or TNF-α Release from Human Hepatic Stellate Cells
por: Robert, Sacha, et al.
Publicado: (2016)

Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies
por: Roy, R, et al.
Publicado: (2014)

Cinobufacini Inhibits the Development of Pancreatic Cancer Cells through the TGFβ/Smads Pathway of Pancreatic Stellate Cells
por: Li, Quan-Wang, et al.
Publicado: (2022)

Gamma-delta T cells stimulate IL-6 production by pancreatic stellate cells in pancreatic ductal adenocarcinoma
por: Seifert, Adrian M., et al.
Publicado: (2020)

Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence
por: Sántha, Petra, et al.
Publicado: (2021)

Ion channels in control of pancreatic stellate cell migration
por: Storck, Hannah, et al.
Publicado: (2016)

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis
por: Ng, Benjamin, et al.
Publicado: (2022)

Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
por: Bramhall, S. R., et al.
Publicado: (1996)

Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
por: McCarroll, Joshua A., et al.
Publicado: (2014)

IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth
por: Li, Jiahui, et al.
Publicado: (2021)

FAPα in pancreatic stellate cells upregulated by TGFβ1: a novel insight into pancreatic cancer progress
por: Xue, Yonggan, et al.
Publicado: (2020)

Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
por: Amrutkar, Manoj, et al.
Publicado: (2022)

Inactivation of Pancreatic Stellate Cells by Exendin-4 Inhibits the Migration and Invasion of Pancreatic Cancer Cells
por: Yan, Meizhu, et al.
Publicado: (2020)

Pancreatic stellate cells facilitate pancreatic cancer cell viability and invasion
por: Liu, Shang-Long, et al.
Publicado: (2019)

Pancreatic stellate cell: Pandora's box for pancreatic disease biology
por: Bynigeri, Ratnakar R, et al.
Publicado: (2017)

A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells
por: Xue, Ran, et al.
Publicado: (2018)

Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis
por: Chang, Man, et al.
Publicado: (2023)

Molecular Mechanism of Pancreatic Stellate Cells Activation in Chronic Pancreatitis and Pancreatic Cancer
por: Jin, Guihua, et al.
Publicado: (2020)

TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling
por: Park, Sang-A, et al.
Publicado: (2015)

Interaction of Stellate Cells with Pancreatic Carcinoma Cells
por: Habisch, Hansjörg, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_1s8i1vaiugdbh7sqtkhjvft195