Cargando…
Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer
Thyroid nodules are a very common problem. Since malignant thyroid nodules should be treated surgically, preoperative diagnosis of thyroid cancer is very crucial. Cytopathologic analysis of percutaneous fine-needle aspiration (FNA) specimens is the current gold standard for diagnosing thyroid nodule...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954945/ https://www.ncbi.nlm.nih.gov/pubmed/27440433 http://dx.doi.org/10.1038/srep30075 |
_version_ | 1782443862526001152 |
---|---|
author | Ryoo, Inseon Kwon, Hyuknam Kim, Soo Chin Jung, Seung Chai Yeom, Jeong A Shin, Hwa Seon Cho, Hye Rim Yun, Tae Jin Choi, Seung Hong Sohn, Chul-Ho Park, Sunghyouk Kim, Ji-hoon |
author_facet | Ryoo, Inseon Kwon, Hyuknam Kim, Soo Chin Jung, Seung Chai Yeom, Jeong A Shin, Hwa Seon Cho, Hye Rim Yun, Tae Jin Choi, Seung Hong Sohn, Chul-Ho Park, Sunghyouk Kim, Ji-hoon |
author_sort | Ryoo, Inseon |
collection | PubMed |
description | Thyroid nodules are a very common problem. Since malignant thyroid nodules should be treated surgically, preoperative diagnosis of thyroid cancer is very crucial. Cytopathologic analysis of percutaneous fine-needle aspiration (FNA) specimens is the current gold standard for diagnosing thyroid nodules. However, this method has led to high rates of inconclusive results. Metabolomics has emerged as a useful tool in medical fields and shown great potential in diagnosing various cancers. Here, we evaluated the potential of nuclear magnetic resonance (NMR) analysis of percutaneous FNA specimens for preoperative diagnosis of thyroid cancer. We analyzed metabolome of FNA samples of papillary thyroid carcinoma (n = 35) and benign follicular nodule (n = 69) using a proton NMR spectrometer. The metabolomic profiles showed a considerable discrimination between benign and malignant nodules. Receiver operating characteristic (ROC) curve analysis indicated that seven metabolites could serve as discriminators (area under ROC curve value, 0.64–0.85). These findings demonstrated that NMR analysis of percutaneous FNA specimens of thyroid nodules can be potentially useful in the accurate and rapid preoperative diagnosis of thyroid cancer. |
format | Online Article Text |
id | pubmed-4954945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49549452016-07-26 Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer Ryoo, Inseon Kwon, Hyuknam Kim, Soo Chin Jung, Seung Chai Yeom, Jeong A Shin, Hwa Seon Cho, Hye Rim Yun, Tae Jin Choi, Seung Hong Sohn, Chul-Ho Park, Sunghyouk Kim, Ji-hoon Sci Rep Article Thyroid nodules are a very common problem. Since malignant thyroid nodules should be treated surgically, preoperative diagnosis of thyroid cancer is very crucial. Cytopathologic analysis of percutaneous fine-needle aspiration (FNA) specimens is the current gold standard for diagnosing thyroid nodules. However, this method has led to high rates of inconclusive results. Metabolomics has emerged as a useful tool in medical fields and shown great potential in diagnosing various cancers. Here, we evaluated the potential of nuclear magnetic resonance (NMR) analysis of percutaneous FNA specimens for preoperative diagnosis of thyroid cancer. We analyzed metabolome of FNA samples of papillary thyroid carcinoma (n = 35) and benign follicular nodule (n = 69) using a proton NMR spectrometer. The metabolomic profiles showed a considerable discrimination between benign and malignant nodules. Receiver operating characteristic (ROC) curve analysis indicated that seven metabolites could serve as discriminators (area under ROC curve value, 0.64–0.85). These findings demonstrated that NMR analysis of percutaneous FNA specimens of thyroid nodules can be potentially useful in the accurate and rapid preoperative diagnosis of thyroid cancer. Nature Publishing Group 2016-07-21 /pmc/articles/PMC4954945/ /pubmed/27440433 http://dx.doi.org/10.1038/srep30075 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Ryoo, Inseon Kwon, Hyuknam Kim, Soo Chin Jung, Seung Chai Yeom, Jeong A Shin, Hwa Seon Cho, Hye Rim Yun, Tae Jin Choi, Seung Hong Sohn, Chul-Ho Park, Sunghyouk Kim, Ji-hoon Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer |
title | Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer |
title_full | Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer |
title_fullStr | Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer |
title_full_unstemmed | Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer |
title_short | Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer |
title_sort | metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: potential application for the preoperative diagnosis of thyroid cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954945/ https://www.ncbi.nlm.nih.gov/pubmed/27440433 http://dx.doi.org/10.1038/srep30075 |
work_keys_str_mv | AT ryooinseon metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT kwonhyuknam metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT kimsoochin metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT jungseungchai metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT yeomjeonga metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT shinhwaseon metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT chohyerim metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT yuntaejin metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT choiseunghong metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT sohnchulho metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT parksunghyouk metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer AT kimjihoon metabolomicanalysisofpercutaneousfineneedleaspirationspecimensofthyroidnodulespotentialapplicationforthepreoperativediagnosisofthyroidcancer |