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New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation
A need exists to noninvasively assess renal interstitial fibrosis, a common process to all kidney diseases and predictive of renal prognosis. In this translational study, Magnetic Resonance Imaging (MRI) T1 mapping and a new segmented Diffusion-Weighted Imaging (DWI) technique, for Apparent Diffusio...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954968/ https://www.ncbi.nlm.nih.gov/pubmed/27439482 http://dx.doi.org/10.1038/srep30088 |
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author | Friedli, I. Crowe, L. A. Berchtold, L. Moll, S. Hadaya, K. de Perrot, T. Vesin, C. Martin, P.-Y. de Seigneux, S. Vallée, J.-P. |
author_facet | Friedli, I. Crowe, L. A. Berchtold, L. Moll, S. Hadaya, K. de Perrot, T. Vesin, C. Martin, P.-Y. de Seigneux, S. Vallée, J.-P. |
author_sort | Friedli, I. |
collection | PubMed |
description | A need exists to noninvasively assess renal interstitial fibrosis, a common process to all kidney diseases and predictive of renal prognosis. In this translational study, Magnetic Resonance Imaging (MRI) T1 mapping and a new segmented Diffusion-Weighted Imaging (DWI) technique, for Apparent Diffusion Coefficient (ADC), were first compared to renal fibrosis in two well-controlled animal models to assess detection limits. Validation against biopsy was then performed in 33 kidney allograft recipients (KARs). Predictive MRI indices, ΔT1 and ΔADC (defined as the cortico-medullary differences), were compared to histology. In rats, both T1 and ADC correlated well with fibrosis and inflammation showing a difference between normal and diseased kidneys. In KARs, MRI indices were not sensitive to interstitial inflammation. By contrast, ΔADC outperformed ΔT1 with a stronger negative correlation to fibrosis (R(2) = 0.64 against R(2) = 0.29 p < 0.001). ΔADC tends to negative values in KARs harboring cortical fibrosis of more than 40%. Using a discriminant analysis method, the ΔADC, as a marker to detect such level of fibrosis or higher, led to a specificity and sensitivity of 100% and 71%, respectively. This new index has potential for noninvasive assessment of fibrosis in the clinical setting. |
format | Online Article Text |
id | pubmed-4954968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49549682016-07-26 New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation Friedli, I. Crowe, L. A. Berchtold, L. Moll, S. Hadaya, K. de Perrot, T. Vesin, C. Martin, P.-Y. de Seigneux, S. Vallée, J.-P. Sci Rep Article A need exists to noninvasively assess renal interstitial fibrosis, a common process to all kidney diseases and predictive of renal prognosis. In this translational study, Magnetic Resonance Imaging (MRI) T1 mapping and a new segmented Diffusion-Weighted Imaging (DWI) technique, for Apparent Diffusion Coefficient (ADC), were first compared to renal fibrosis in two well-controlled animal models to assess detection limits. Validation against biopsy was then performed in 33 kidney allograft recipients (KARs). Predictive MRI indices, ΔT1 and ΔADC (defined as the cortico-medullary differences), were compared to histology. In rats, both T1 and ADC correlated well with fibrosis and inflammation showing a difference between normal and diseased kidneys. In KARs, MRI indices were not sensitive to interstitial inflammation. By contrast, ΔADC outperformed ΔT1 with a stronger negative correlation to fibrosis (R(2) = 0.64 against R(2) = 0.29 p < 0.001). ΔADC tends to negative values in KARs harboring cortical fibrosis of more than 40%. Using a discriminant analysis method, the ΔADC, as a marker to detect such level of fibrosis or higher, led to a specificity and sensitivity of 100% and 71%, respectively. This new index has potential for noninvasive assessment of fibrosis in the clinical setting. Nature Publishing Group 2016-07-21 /pmc/articles/PMC4954968/ /pubmed/27439482 http://dx.doi.org/10.1038/srep30088 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Friedli, I. Crowe, L. A. Berchtold, L. Moll, S. Hadaya, K. de Perrot, T. Vesin, C. Martin, P.-Y. de Seigneux, S. Vallée, J.-P. New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation |
title | New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison
between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation |
title_full | New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison
between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation |
title_fullStr | New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison
between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation |
title_full_unstemmed | New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison
between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation |
title_short | New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison
between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation |
title_sort | new magnetic resonance imaging index for renal fibrosis assessment: a comparison
between diffusion-weighted imaging and t1 mapping with histological validation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954968/ https://www.ncbi.nlm.nih.gov/pubmed/27439482 http://dx.doi.org/10.1038/srep30088 |
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