High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers

Checkpoint-blocking antibodies like those targeting the PD-1/PD-L1 pathway have revolutionized oncology. We developed radiotracers based on therapeutic checkpoint-blocking antibodies permitting sensitive and high-resolution PET imaging of both PD-1 and PD-L1 in immunocompetent mice. ImmunoPET of nai...

Descripción completa

Detalles Bibliográficos
Autores principales: Hettich, Michael, Braun, Friederike, Bartholomä, Mark D., Schirmbeck, Reinhold, Niedermann, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955062/
https://www.ncbi.nlm.nih.gov/pubmed/27446497
http://dx.doi.org/10.7150/thno.15253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955062/
https://www.ncbi.nlm.nih.gov/pubmed/27446497
http://dx.doi.org/10.7150/thno.15253

Ejemplares similares