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An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report
BACKGROUND: Membranoproliferative glomerulonephritis is a common pattern of glomerular injury in monoclonal gammopathy, but has only rarely been associated with solid organ tumors, mainly lung, renal, gastric, breast, and prostate. There have been two reported cases of membranoproliferative glomerul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955154/ https://www.ncbi.nlm.nih.gov/pubmed/27439394 http://dx.doi.org/10.1186/s13256-016-0979-3 |
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author | Chan, Samuel Oliver, Kimberley A. Gray, Nicholas A. |
author_facet | Chan, Samuel Oliver, Kimberley A. Gray, Nicholas A. |
author_sort | Chan, Samuel |
collection | PubMed |
description | BACKGROUND: Membranoproliferative glomerulonephritis is a common pattern of glomerular injury in monoclonal gammopathy, but has only rarely been associated with solid organ tumors, mainly lung, renal, gastric, breast, and prostate. There have been two reported cases of membranoproliferative glomerulonephritis associated with adenocarcinoma of the colon and rectum, although the association may be coincidental. We report a case where nephrotic syndrome due to membranoproliferative glomerulonephritis developed in a patient with colorectal carcinoma and elucidate some of the pathophysiological mechanisms underpinning this presentation. CASE PRESENTATION: A 54-year-old white man with a history of adenocarcinoma of the colon with metastasis to the liver and ureter presented with a 1-week history of bilateral pedal edema, and worsening hypertension and renal function. A renal biopsy confirmed membranoproliferative glomerulonephritis type I. Curative therapy for the malignancy was not possible, so treatment was commenced with prednisolone with consequential biochemical improvement in renal function and proteinuria, although his serum albumin remained low. CONCLUSIONS: This case report illustrates an association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma and adds to the evidence to consider malignancy to be an underlying pathology among newly diagnosed cases of nephrotic syndrome. In the clinical setting, treatment of the underlying malignancy should be first considered in patients with a tumor presenting with kidney disease which is suspected to be paraneoplastic in etiology. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13256-016-0979-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4955154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49551542016-07-22 An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report Chan, Samuel Oliver, Kimberley A. Gray, Nicholas A. J Med Case Rep Case Report BACKGROUND: Membranoproliferative glomerulonephritis is a common pattern of glomerular injury in monoclonal gammopathy, but has only rarely been associated with solid organ tumors, mainly lung, renal, gastric, breast, and prostate. There have been two reported cases of membranoproliferative glomerulonephritis associated with adenocarcinoma of the colon and rectum, although the association may be coincidental. We report a case where nephrotic syndrome due to membranoproliferative glomerulonephritis developed in a patient with colorectal carcinoma and elucidate some of the pathophysiological mechanisms underpinning this presentation. CASE PRESENTATION: A 54-year-old white man with a history of adenocarcinoma of the colon with metastasis to the liver and ureter presented with a 1-week history of bilateral pedal edema, and worsening hypertension and renal function. A renal biopsy confirmed membranoproliferative glomerulonephritis type I. Curative therapy for the malignancy was not possible, so treatment was commenced with prednisolone with consequential biochemical improvement in renal function and proteinuria, although his serum albumin remained low. CONCLUSIONS: This case report illustrates an association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma and adds to the evidence to consider malignancy to be an underlying pathology among newly diagnosed cases of nephrotic syndrome. In the clinical setting, treatment of the underlying malignancy should be first considered in patients with a tumor presenting with kidney disease which is suspected to be paraneoplastic in etiology. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13256-016-0979-3) contains supplementary material, which is available to authorized users. BioMed Central 2016-07-20 /pmc/articles/PMC4955154/ /pubmed/27439394 http://dx.doi.org/10.1186/s13256-016-0979-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Chan, Samuel Oliver, Kimberley A. Gray, Nicholas A. An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report |
title | An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report |
title_full | An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report |
title_fullStr | An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report |
title_full_unstemmed | An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report |
title_short | An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report |
title_sort | association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955154/ https://www.ncbi.nlm.nih.gov/pubmed/27439394 http://dx.doi.org/10.1186/s13256-016-0979-3 |
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