Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

BACKGROUND: The poor prognosis and the limited efficacy of targeted therapy in patients with triple-negative breast cancer (TNBC) have raised the need for alternative therapies. Recent studies have demonstrated that folate receptor-alpha (FRα) may represent an ideal tumor-associated marker for immun...

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Detalles Bibliográficos
Autores principales: Song, De-Gang, Ye, Qunrui, Poussin, Mathilde, Chacon, Jessica A., Figini, Mariangela, Powell, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955216/
https://www.ncbi.nlm.nih.gov/pubmed/27439908
http://dx.doi.org/10.1186/s13045-016-0285-y

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