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Synthesis of d‐ and l‐Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process
The synthesis of substituted d‐phenylalanines in high yield and excellent optical purity, starting from inexpensive cinnamic acids, has been achieved with a novel one‐pot approach by coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymatic deracemization (based on stereoselective o...
Autores principales: | Parmeggiani, Fabio, Lovelock, Sarah L., Weise, Nicholas J., Ahmed, Syed T., Turner, Nicholas J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY‐VCH Verlag
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955227/ https://www.ncbi.nlm.nih.gov/pubmed/27478261 http://dx.doi.org/10.1002/ange.201410670 |
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