Human memory T cells with a naïve phenotype accumulate with aging and respond to persistent viruses

The numbers of naive T cells decrease, and the susceptibility to new microbial infections increases with age. Here, we describe a new subset of phenotypically naive human CD8(+)T cells that rapidly secrete multiple cytokines in response to persistent viral antigens but differ transcriptionally from...

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Detalles Bibliográficos
Autores principales: Pulko, Vesna, Davies, John S., Martinez, Carmine, Lanteri, Marion C., Busch, Michael P., Diamond, Michael S., Knox, Kenneth, Busch, Erin S., Sims, Peter A., Sinari, Shripad, Billheimer, Dean, Haddad, Elias K., Murray, Kristy O., Wertheimer, Anne M., Nikolich-Žugich, Janko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955715/
https://www.ncbi.nlm.nih.gov/pubmed/27270402
http://dx.doi.org/10.1038/ni.3483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955715/
https://www.ncbi.nlm.nih.gov/pubmed/27270402
http://dx.doi.org/10.1038/ni.3483

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