Control of the innate immune response by the mevalonate pathway

Deficiency of mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate (GGPP), a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylat...

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Detalles Bibliográficos
Autores principales: Akula, Murali K., Shi, Man, Jiang, Zhaozhao, Foster, Celia E., Miao, David, Li, Annie S., Zhang, Xiaoman, Gavin, Ruth M., Forde, Sorcha D., Germain, Gail, Carpenter, Susan, Rosadini, Charles V., Gritsman, Kira, Chae, Jae Jin, Hampton, Randolph, Silverman, Neal, Gravallese, Ellen M., Kagan, Jonathan C., Fitzgerald, Katherine A., Kastner, Daniel L., Golenbock, Douglas T., Bergo, Martin O., Wang, Donghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955724/
https://www.ncbi.nlm.nih.gov/pubmed/27270400
http://dx.doi.org/10.1038/ni.3487

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