Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment

During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on the transcription factor Bcl11b. To clarify lineage commitment mechanisms, we followed developing T cells at single-cell level using Bcl11b knock-in fluorescent rep...

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Detalles Bibliográficos
Autores principales: Kueh, Hao Yuan, Yui, Mary A., Ng, Kenneth K.H., Pease, Shirley S., Zhang, Jingli A., Damle, Sagar S., Freedman, George, Siu, Sharmayne, Bernstein, Irwin D., Elowitz, Michael B., Rothenberg, Ellen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955789/
https://www.ncbi.nlm.nih.gov/pubmed/27376470
http://dx.doi.org/10.1038/ni.3514

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