Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain

BACKGROUND: A growing body of evidence suggests that ATP-gated P2X3 receptors (P2X3Rs) are implicated in chronic pain. We address the possibility that stable, synthetic analogs of diadenosine tetraphosphate (Ap(4)A) might induce antinociceptive effects by inhibiting P2X3Rs in peripheral sensory neur...

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Detalles Bibliográficos
Autores principales: Viatchenko-Karpinski, Viacheslav, Novosolova, Natalia, Ishchenko, Yevheniia, Azhar, M Ameruddin, Wright, Michael, Tsintsadze, Vera, Kamal, Ahmed, Burnashev, Nail, Miller, Andrew D, Voitenko, Nana, Giniatullin, Rashid, Lozovaya, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955970/
https://www.ncbi.nlm.nih.gov/pubmed/27030723
http://dx.doi.org/10.1177/1744806916637704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955970/
https://www.ncbi.nlm.nih.gov/pubmed/27030723
http://dx.doi.org/10.1177/1744806916637704

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