CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22(R619W) Mutation Increases Autoimmune Diabetes

An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN22(R620W), is strongly associated with type 1 diabetes (T1D) in humans and increases the risk of T1D by two- to fourfold. The NOD mouse is a spontaneous T1D model that shares with humans many genetic pathways contri...

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Detalles Bibliográficos
Autores principales: Lin, Xiaotian, Pelletier, Stephane, Gingras, Sebastien, Rigaud, Stephanie, Maine, Christian J., Marquardt, Kristi, Dai, Yang D., Sauer, Karsten, Rodriguez, Alberto R., Martin, Greg, Kupriyanov, Sergey, Jiang, Ling, Yu, Liping, Green, Douglas R., Sherman, Linda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Technological Advances
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955979/
https://www.ncbi.nlm.nih.gov/pubmed/27207523
http://dx.doi.org/10.2337/db16-0061

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