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Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function

To determine the roles of insulin and insulin-like growth factor 1 (IGF-1) action in adipose tissue, we created mice lacking the insulin receptor (IR), IGF-1 receptor (IGF1R), or both using Cre-recombinase driven by the adiponectin promoter. Mice lacking IGF1R only (F-IGFRKO) had a ∼25% reduction in...

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Detalles Bibliográficos
Autores principales:	Boucher, Jeremie, Softic, Samir, El Ouaamari, Abdelfattah, Krumpoch, Megan T., Kleinridders, Andre, Kulkarni, Rohit N., O’Neill, Brian T., Kahn, C. Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955980/ https://www.ncbi.nlm.nih.gov/pubmed/27207537 http://dx.doi.org/10.2337/db16-0212

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