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In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs...

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Detalles Bibliográficos
Autores principales:	ElHefnawi, Mahmoud, Kim, TaeKyu, Kamar, Mona A., Min, Saehong, Hassan, Nafisa M., El-Ahwany, Eman, Kim, Heeyoung, Zada, Suher, Amer, Marwa, Windisch, Marc P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956106/ https://www.ncbi.nlm.nih.gov/pubmed/27441640 http://dx.doi.org/10.1371/journal.pone.0159211

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