Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1

Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in col...

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Detalles Bibliográficos
Autores principales: Kim, Sun-Hee, Park, Yun-Yong, Cho, Sung-Nam, Margalit, Ofer, Wang, Dingzhi, DuBois, Raymond N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956169/
https://www.ncbi.nlm.nih.gov/pubmed/27442508
http://dx.doi.org/10.1371/journal.pone.0159899
Descripción
Sumario:Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.

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