Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1

Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in col...

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Detalles Bibliográficos
Autores principales: Kim, Sun-Hee, Park, Yun-Yong, Cho, Sung-Nam, Margalit, Ofer, Wang, Dingzhi, DuBois, Raymond N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956169/
https://www.ncbi.nlm.nih.gov/pubmed/27442508
http://dx.doi.org/10.1371/journal.pone.0159899
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author Kim, Sun-Hee
Park, Yun-Yong
Cho, Sung-Nam
Margalit, Ofer
Wang, Dingzhi
DuBois, Raymond N.
author_facet Kim, Sun-Hee
Park, Yun-Yong
Cho, Sung-Nam
Margalit, Ofer
Wang, Dingzhi
DuBois, Raymond N.
author_sort Kim, Sun-Hee
collection PubMed
description Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.
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spelling pubmed-49561692016-08-08 Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1 Kim, Sun-Hee Park, Yun-Yong Cho, Sung-Nam Margalit, Ofer Wang, Dingzhi DuBois, Raymond N. PLoS One Research Article Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target. Public Library of Science 2016-07-21 /pmc/articles/PMC4956169/ /pubmed/27442508 http://dx.doi.org/10.1371/journal.pone.0159899 Text en © 2016 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kim, Sun-Hee
Park, Yun-Yong
Cho, Sung-Nam
Margalit, Ofer
Wang, Dingzhi
DuBois, Raymond N.
Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1
title Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1
title_full Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1
title_fullStr Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1
title_full_unstemmed Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1
title_short Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1
title_sort krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956169/
https://www.ncbi.nlm.nih.gov/pubmed/27442508
http://dx.doi.org/10.1371/journal.pone.0159899
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