Epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure

BACKGROUND: Opioids have become the mainstay for treatment of moderate to severe pain and are commonly used to treat surgical pain. While opioid administration has been shown to cause opioid-induced hyperalgesia and tolerance, interactions between opioid administration and surgery with respect to th...

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Detalles Bibliográficos
Autores principales: Sahbaie, Peyman, Liang, De-Yong, Shi, Xiao-You, Sun, Yuan, Clark, J David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956243/
https://www.ncbi.nlm.nih.gov/pubmed/27094549
http://dx.doi.org/10.1177/1744806916641950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956243/
https://www.ncbi.nlm.nih.gov/pubmed/27094549
http://dx.doi.org/10.1177/1744806916641950

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