Host-Pathogen Coevolution and the Emergence of Broadly Neutralizing Antibodies in Chronic Infections

The vertebrate adaptive immune system provides a flexible and diverse set of molecules to neutralize pathogens. Yet, viruses such as HIV can cause chronic infections by evolving as quickly as the adaptive immune system, forming an evolutionary arms race. Here we introduce a mathematical framework to...

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Detalles Bibliográficos
Autores principales: Nourmohammad, Armita, Otwinowski, Jakub, Plotkin, Joshua B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956326/
https://www.ncbi.nlm.nih.gov/pubmed/27442127
http://dx.doi.org/10.1371/journal.pgen.1006171

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