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Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury

BACKGROUND: Spared nerve injury is an important neuropathic pain model for investigating the role of intact primary afferents in the skin on pain hypersensitivity. However, potential cellular mechanisms remain poorly understood. In phosphoinositide-3 kinase pathway, pyruvate dehydrogenase kinase 1 (...

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Detalles Bibliográficos
Autores principales: Ko, Miau-Hwa, Yang, Ming-Ling, Youn, Su-Chung, Lan, Chyn-Tair, Tseng, To-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956387/
https://www.ncbi.nlm.nih.gov/pubmed/27296621
http://dx.doi.org/10.1177/1744806916656189