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Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties

BACKGROUND: T-type calcium channels are important contributors to signaling in the primary afferent pain pathway and are thus important targets for the development of analgesics. It has been previously reported that certain piperazine-based compounds such as flunarizine are able to inhibit T-type ca...

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Detalles Bibliográficos
Autores principales:	Pudukulatham, Zubaidha, Zhang, Fang-Xiong, Gadotti, Vinicius M, M’Dahoma, Said, Swami, Prabhuling, Tamboli, Yasinalli, Zamponi, Gerald W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956396/ https://www.ncbi.nlm.nih.gov/pubmed/27053601 http://dx.doi.org/10.1177/1744806916641678

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