PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1

Loss of the genome maintenance factor Elg1 causes serious genome instability that leads to cancer, but the underlying mechanism is unknown. Elg1 forms the major subunit of a replication factor C-like complex, Elg1-RLC, which unloads the ring-shaped polymerase clamp PCNA from DNA during replication....

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Detalles Bibliográficos
Autores principales: Johnson, Catherine, Gali, Vamsi K., Takahashi, Tatsuro S., Kubota, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956615/
https://www.ncbi.nlm.nih.gov/pubmed/27373149
http://dx.doi.org/10.1016/j.celrep.2016.06.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956615/
https://www.ncbi.nlm.nih.gov/pubmed/27373149
http://dx.doi.org/10.1016/j.celrep.2016.06.030

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