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PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1
Loss of the genome maintenance factor Elg1 causes serious genome instability that leads to cancer, but the underlying mechanism is unknown. Elg1 forms the major subunit of a replication factor C-like complex, Elg1-RLC, which unloads the ring-shaped polymerase clamp PCNA from DNA during replication....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956615/ https://www.ncbi.nlm.nih.gov/pubmed/27373149 http://dx.doi.org/10.1016/j.celrep.2016.06.030 |