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Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report

BACKGROUND: It has been known that plasmablastic lymphoma (PBL) is a neoplasm of immunocompromised patients occurring in soft tissue of oral cavity or in the vicinity whereas bone is an unlikely site to harbor PBL. However, its occurrence is increasingly being reported in immunocompetent individuals...

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Autores principales: Sarker, Azmal Kabir, Im, Hyung-Jun, Paeng, Jin Chul, Cheon, Gi Jeong, Kang, Keon Wook, Chung, June-Key, Lee, Dong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956826/
https://www.ncbi.nlm.nih.gov/pubmed/27428232
http://dx.doi.org/10.1097/MD.0000000000004241
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author Sarker, Azmal Kabir
Im, Hyung-Jun
Paeng, Jin Chul
Cheon, Gi Jeong
Kang, Keon Wook
Chung, June-Key
Lee, Dong Soo
author_facet Sarker, Azmal Kabir
Im, Hyung-Jun
Paeng, Jin Chul
Cheon, Gi Jeong
Kang, Keon Wook
Chung, June-Key
Lee, Dong Soo
author_sort Sarker, Azmal Kabir
collection PubMed
description BACKGROUND: It has been known that plasmablastic lymphoma (PBL) is a neoplasm of immunocompromised patients occurring in soft tissue of oral cavity or in the vicinity whereas bone is an unlikely site to harbor PBL. However, its occurrence is increasingly being reported in immunocompetent individuals in either osseous or extra-oral sites. To our best knowledge, F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient have not been reported, yet . CASE SUMMARY: We report a case of PBL involving multiple bones in an immunocompetent patient. Features of different imaging modalities including F-18 Fluoro-deoxy glucose (FDG) positron emission tomography/computed tomography (PET/CT) were correlated well as findings of osteosarcoma in mandible with metastatic lesions. However, the histopathology and immunohistochemistry (IHC) of bone tissues from 2 separate biopsy sites revealed features of PBL. CONCLUSION: awareness to F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient may prevent misdiagnosis.
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spelling pubmed-49568262016-08-02 Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report Sarker, Azmal Kabir Im, Hyung-Jun Paeng, Jin Chul Cheon, Gi Jeong Kang, Keon Wook Chung, June-Key Lee, Dong Soo Medicine (Baltimore) 4100 BACKGROUND: It has been known that plasmablastic lymphoma (PBL) is a neoplasm of immunocompromised patients occurring in soft tissue of oral cavity or in the vicinity whereas bone is an unlikely site to harbor PBL. However, its occurrence is increasingly being reported in immunocompetent individuals in either osseous or extra-oral sites. To our best knowledge, F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient have not been reported, yet . CASE SUMMARY: We report a case of PBL involving multiple bones in an immunocompetent patient. Features of different imaging modalities including F-18 Fluoro-deoxy glucose (FDG) positron emission tomography/computed tomography (PET/CT) were correlated well as findings of osteosarcoma in mandible with metastatic lesions. However, the histopathology and immunohistochemistry (IHC) of bone tissues from 2 separate biopsy sites revealed features of PBL. CONCLUSION: awareness to F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient may prevent misdiagnosis. Wolters Kluwer Health 2016-07-18 /pmc/articles/PMC4956826/ /pubmed/27428232 http://dx.doi.org/10.1097/MD.0000000000004241 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4100
Sarker, Azmal Kabir
Im, Hyung-Jun
Paeng, Jin Chul
Cheon, Gi Jeong
Kang, Keon Wook
Chung, June-Key
Lee, Dong Soo
Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report
title Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report
title_full Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report
title_fullStr Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report
title_full_unstemmed Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report
title_short Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report
title_sort plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: a case report
topic 4100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956826/
https://www.ncbi.nlm.nih.gov/pubmed/27428232
http://dx.doi.org/10.1097/MD.0000000000004241
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