The role of BRD7 in embryo development and glucose metabolism

Bromodomain‐containing protein 7 (BRD7) is a member of bromodomain‐containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in...

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Autores principales: Kim, Yoo, Andrés Salazar Hernández, Mario, Herrema, Hilde, Delibasi, Tuncay, Park, Sang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956945/
https://www.ncbi.nlm.nih.gov/pubmed/27444544
http://dx.doi.org/10.1111/jcmm.12907
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author Kim, Yoo
Andrés Salazar Hernández, Mario
Herrema, Hilde
Delibasi, Tuncay
Park, Sang Won
author_facet Kim, Yoo
Andrés Salazar Hernández, Mario
Herrema, Hilde
Delibasi, Tuncay
Park, Sang Won
author_sort Kim, Yoo
collection PubMed
description Bromodomain‐containing protein 7 (BRD7) is a member of bromodomain‐containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid‐gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.
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spelling pubmed-49569452016-08-03 The role of BRD7 in embryo development and glucose metabolism Kim, Yoo Andrés Salazar Hernández, Mario Herrema, Hilde Delibasi, Tuncay Park, Sang Won J Cell Mol Med Original Articles Bromodomain‐containing protein 7 (BRD7) is a member of bromodomain‐containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid‐gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism. John Wiley and Sons Inc. 2016-07-22 2016-08 /pmc/articles/PMC4956945/ /pubmed/27444544 http://dx.doi.org/10.1111/jcmm.12907 Text en © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Kim, Yoo
Andrés Salazar Hernández, Mario
Herrema, Hilde
Delibasi, Tuncay
Park, Sang Won
The role of BRD7 in embryo development and glucose metabolism
title The role of BRD7 in embryo development and glucose metabolism
title_full The role of BRD7 in embryo development and glucose metabolism
title_fullStr The role of BRD7 in embryo development and glucose metabolism
title_full_unstemmed The role of BRD7 in embryo development and glucose metabolism
title_short The role of BRD7 in embryo development and glucose metabolism
title_sort role of brd7 in embryo development and glucose metabolism
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956945/
https://www.ncbi.nlm.nih.gov/pubmed/27444544
http://dx.doi.org/10.1111/jcmm.12907
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