Gene silencing of endothelial von Willebrand Factor attenuates angiotensin II-induced endothelin-1 expression in porcine aortic endothelial cells

Expression of endothelin (ET)-1 is increased in endothelial cells exposed to angiotensin II (Ang II), leading to endothelial dysfunction and cardiovascular disorders. Since von Willebrand Factor (vWF) blockade improves endothelial function in coronary patients, we hypothesized that targeting endothe...

Descripción completa

Detalles Bibliográficos
Autores principales: Dushpanova, Anar, Agostini, Silvia, Ciofini, Enrica, Cabiati, Manuela, Casieri, Valentina, Matteucci, Marco, Del Ry, Silvia, Clerico, Aldo, Berti, Sergio, Lionetti, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957110/
https://www.ncbi.nlm.nih.gov/pubmed/27443965
http://dx.doi.org/10.1038/srep30048

Ejemplares similares

Ejemplares similares