Cargando…

TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

The hMSCs have become a promising approach for inflammation treatment in acute phase. Our previous study has demonstrated that human umbilical cord-MSCs could alleviate the inflammatory reaction of severely burned wound. In this study, we further investigated the potential role and mechanism of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Lingying, Song, Huifeng, Duan, Hongjie, Chai, Jiake, Yang, Jing, Li, Xiao, Yu, Yonghui, Zhang, Xulong, Hu, Xiaohong, Xiao, Mengjing, Feng, Rui, Yin, Huinan, Hu, Quan, Yang, Longlong, Du, Jundong, Li, Tianran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957124/ https://www.ncbi.nlm.nih.gov/pubmed/27444207 http://dx.doi.org/10.1038/srep30121

Ejemplares similares

Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation
por: Li, Xiao, et al.
Publicado: (2016)

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Acute Lung Injury Caused by Severe Burn via Secreting TSG-6 and Inhibiting Inflammatory Response
por: Hu, Xiaohong, et al.
Publicado: (2022)

Human Umbilical Cord Mesenchymal Stem Cells Transplantation Promotes Cutaneous Wound Healing of Severe Burned Rats
por: Liu, Lingying, et al.
Publicado: (2014)

miR-628 Promotes Burn-Induced Skeletal Muscle Atrophy via Targeting IRS1
por: Yu, Yonghui, et al.
Publicado: (2016)

Effect of celecoxib in treatment of burn-induced hypermetabolism
por: Zhuang, Shubo, et al.
Publicado: (2020)

TWIST1 and TSG6 are coordinately regulated and function as potency biomarkers in human MSCs
por: Lee, Ryang Hwa, et al.
Publicado: (2023)

Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway
por: Liu, Lingying, et al.
Publicado: (2020)

Therapeutic Effect of TSG-6 Engineered iPSC-Derived MSCs on Experimental Periodontitis in Rats: A Pilot Study
por: Yang, Heng, et al.
Publicado: (2014)

TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity
por: Kota, Daniel J., et al.
Publicado: (2013)

Establishment of a Bama miniature pig burn model with different burn depths
por: Hao, Xingxia, et al.
Publicado: (2022)

Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair
por: Zhang, Ning, et al.
Publicado: (2020)

Influence of Umbilical Cord Blood Biochemical Parameters and Disease Condition on the Expression of the TSG-6 Gene in Umbilical Mesenchymal Stem Cells
por: Ozygała, Aleksandra, et al.
Publicado: (2023)

Human Umbilical Cord Mesenchymal Stem Cells Attenuate Severe Burn-Induced Multiple Organ Injury via Potentiating IGF-1 and BCL-2/BAX Pathway
por: Wang, Hongyu, et al.
Publicado: (2022)

Effect of small molecular weight soybean protein-derived peptide supplementation on attenuating burn injury-induced inflammation and accelerating wound healing in a rat model
por: Zhao, Fen, et al.
Publicado: (2019)

The application of umbilical cord‐derived MSCs in cardiovascular diseases
por: Chen, Yueqiu, et al.
Publicado: (2021)

HSD11B1 is upregulated synergistically by IFNγ and TNFα and mediates TSG-6 expression in human UC-MSCs
por: Huang, Peiqing, et al.
Publicado: (2020)

Canine adipose tissue-derived MSCs engineered with mRNA to overexpress TSG-6 and enhance the anti-inflammatory effects in canine macrophages
por: Yun, Ga-Hee, et al.
Publicado: (2023)

MSCs Conditioned Media and Umbilical Cord Blood Plasma Metabolomics and Composition
por: Pereira, Tiago, et al.
Publicado: (2014)

Effect of precise partial scab removal on the repair of deep partial-thickness burn wounds in children: a retrospective study
por: Chi, Yunfei, et al.
Publicado: (2021)

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway
por: Liang, Chenyu, et al.
Publicado: (2021)

Testis-Specific GTPase (TSG): An oligomeric protein
por: Kumar, Sudeep, et al.
Publicado: (2016)

Identification of TSG101 Functional Domains and p21 Loci Required for TSG101-Mediated p21 Gene Regulation
por: Lin, Yu-Shiuan, et al.
Publicado: (2013)

Umbilical Cord MSCs and Their Secretome in the Therapy of Arthritic Diseases: A Research and Industrial Perspective
por: Arrigoni, Chiara, et al.
Publicado: (2020)

Upregulated TSG-6 Expression in ADSCs Inhibits the BV2 Microglia-Mediated Inflammatory Response
por: Hu, Yang, et al.
Publicado: (2018)

Human Umbilical Cord Mesenchymal Stem Cells-Secreted TSG-6 Is Anti-Inflammatory and Promote Tissue Repair After Spinal Cord Injury
por: Liao, Ziling, et al.
Publicado: (2021)

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration
por: Jiao, Jian, et al.
Publicado: (2009)

TSG101 negatively regulates mitochondrial biogenesis in axons
por: Lin, Tzu-Huai, et al.
Publicado: (2021)

TSGΔ154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation
por: Chua, Huey-Huey, et al.
Publicado: (2016)

Mesenchymal Stem Cells Attenuate Peritoneal Injury through Secretion of TSG-6
por: Wang, Nan, et al.
Publicado: (2012)

Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury
por: Ren, Haitao, et al.
Publicado: (2018)

Improved osteogenic differentiation of umbilical cord blood MSCs using custom made perfusion bioreactor
por: Birru, Bhaskar, et al.
Publicado: (2018)

The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson's Disease
por: Jinfeng, Li, et al.
Publicado: (2016)

A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6
por: Yang, Shaopeng, et al.
Publicado: (2021)

Liver-targeted delivery of TSG-6 by calcium phosphate nanoparticles for the management of liver fibrosis
por: Wang, Min, et al.
Publicado: (2020)

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis
por: Ning, Yujie, et al.
Publicado: (2022)

Different mutational characteristics of TSG in cell lines and surgical specimens
por: Stoczynska-Fidelus, Ewelina, et al.
Publicado: (2014)

Human Umbilical Cord MSCs as New Cell Sources for Promoting Periodontal Regeneration in Inflammatory Periodontal Defect
por: Shang, Fengqing, et al.
Publicado: (2017)

Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
por: Yang, Chunjuan, et al.
Publicado: (2021)

The role of MSCs and CAR-MSCs in cellular immunotherapy
por: Yan, Lun, et al.
Publicado: (2023)

Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with “F-5” Gene
por: Leng, Xiangfeng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ffhsnmeu90hqfm08smlgov3c6p