DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Mutations in the epigenetic modifiers DNMT3A and TET2 non-randomly co-occur in lymphoma and leukemia despite their epistasis in the methylation-hydroxymethylation pathway. Using Dnmt3a and Tet2 double knock-out (DKO) mice in which malignancy development is accelerated, we show that the DKO methylome...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaotian, Su, Jianzhong, Jeong, Mira, Ko, Myunggon, Huang, Yun, Park, Hyun Jung, Guzman, Anna, Lei, Yong, Huang, Yung-Hsin, Rao, Anjana, Li, Wei, Goodell, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957136/
https://www.ncbi.nlm.nih.gov/pubmed/27428748
http://dx.doi.org/10.1038/ng.3610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957136/
https://www.ncbi.nlm.nih.gov/pubmed/27428748
http://dx.doi.org/10.1038/ng.3610

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