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Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion
Perfusion of the penumbra tissue below the flow threshold for functional disturbance but above that for the maintenance of morphological integrity is the target for therapy in acute ischaemic stroke. The measurement of the oxygen extraction fraction (OEF) may provide a direct assessment of tissue vi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957224/ https://www.ncbi.nlm.nih.gov/pubmed/27443195 http://dx.doi.org/10.1038/srep30332 |
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author | Chang, Fei-Yan Xiao, Jiang-Xi Xie, Sheng Yu, Lei Zhang, Zhen-Xia Wang, Wu Luo, Jie Zhang, Zhong-Ping Guo, Hua |
author_facet | Chang, Fei-Yan Xiao, Jiang-Xi Xie, Sheng Yu, Lei Zhang, Zhen-Xia Wang, Wu Luo, Jie Zhang, Zhong-Ping Guo, Hua |
author_sort | Chang, Fei-Yan |
collection | PubMed |
description | Perfusion of the penumbra tissue below the flow threshold for functional disturbance but above that for the maintenance of morphological integrity is the target for therapy in acute ischaemic stroke. The measurement of the oxygen extraction fraction (OEF) may provide a direct assessment of tissue viability, so that irreversible tissue damage and penumbra can be reliably identified. By using an asymmetric spin echo single-shot echo planar imaging (ASE-SSEPI) sequence, the quantitative OEF was obtained in the ischaemic brain tissues of canine models with internal carotid artery occlusion. TTC staining, which delineated the regions of infarct and penumbra, was used for defining the corresponding regions on OEF maps. The threshold of the OEF to discriminate the infarct cores and penumbral tissues was then determined according to the OEF values at different times. With repeated-measures ANOVA, the OEF of the infarcted regions was found to be time dependent. An OEF greater than 0.48 best predicted cortical infarction at 1.5 hr, with an area under the receiving operating characteristic curve of 0.968, a sensitivity of 97.5%, and a specificity of 92.5%. Our results may be helpful in the evaluation of tissue viability during stroke events. |
format | Online Article Text |
id | pubmed-4957224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49572242016-07-26 Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion Chang, Fei-Yan Xiao, Jiang-Xi Xie, Sheng Yu, Lei Zhang, Zhen-Xia Wang, Wu Luo, Jie Zhang, Zhong-Ping Guo, Hua Sci Rep Article Perfusion of the penumbra tissue below the flow threshold for functional disturbance but above that for the maintenance of morphological integrity is the target for therapy in acute ischaemic stroke. The measurement of the oxygen extraction fraction (OEF) may provide a direct assessment of tissue viability, so that irreversible tissue damage and penumbra can be reliably identified. By using an asymmetric spin echo single-shot echo planar imaging (ASE-SSEPI) sequence, the quantitative OEF was obtained in the ischaemic brain tissues of canine models with internal carotid artery occlusion. TTC staining, which delineated the regions of infarct and penumbra, was used for defining the corresponding regions on OEF maps. The threshold of the OEF to discriminate the infarct cores and penumbral tissues was then determined according to the OEF values at different times. With repeated-measures ANOVA, the OEF of the infarcted regions was found to be time dependent. An OEF greater than 0.48 best predicted cortical infarction at 1.5 hr, with an area under the receiving operating characteristic curve of 0.968, a sensitivity of 97.5%, and a specificity of 92.5%. Our results may be helpful in the evaluation of tissue viability during stroke events. Nature Publishing Group 2016-07-22 /pmc/articles/PMC4957224/ /pubmed/27443195 http://dx.doi.org/10.1038/srep30332 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Chang, Fei-Yan Xiao, Jiang-Xi Xie, Sheng Yu, Lei Zhang, Zhen-Xia Wang, Wu Luo, Jie Zhang, Zhong-Ping Guo, Hua Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion |
title | Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion |
title_full | Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion |
title_fullStr | Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion |
title_full_unstemmed | Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion |
title_short | Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion |
title_sort | determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957224/ https://www.ncbi.nlm.nih.gov/pubmed/27443195 http://dx.doi.org/10.1038/srep30332 |
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