Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice

Terminal complement membrane attack complex (MAC) formation is induced initially by C5b, followed by the sequential condensation of the C6, C7, C8. Polymerization of C9 to the C5b-8 complex forms the C5b-9 (or MAC). The C5b-9 forms lytic or non lytic pores in the cell membrane destroys membrane inte...

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Detalles Bibliográficos
Autores principales: Fu, Xiaoyan, Ju, Jiyu, Lin, Zhijuan, Xiao, Weiling, Li, Xiaofang, Zhuang, Baoxiang, Zhang, Tingting, Ma, Xiaojun, Li, Xiangyu, Ma, Chao, Su, Weiliang, Wang, Yuqi, Qin, Xuebin, Liang, Shujuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957234/
https://www.ncbi.nlm.nih.gov/pubmed/27444648
http://dx.doi.org/10.1038/srep30239

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