Granulomatous interstitial nephritis and Crohn's disease

Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in...

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Detalles Bibliográficos
Autores principales: Timmermans, Sjoerd A.M.E.G., Christiaans, Maarten H.L., Abdul-Hamid, Myrurgia A., Stifft, Frank, Damoiseaux, Jan G.M.C., van Paassen, Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Kidney in Systemic Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957721/
https://www.ncbi.nlm.nih.gov/pubmed/27478596
http://dx.doi.org/10.1093/ckj/sfw041
Descripción
Sumario:Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatment, renal function either improved or stabilized in both patients. In conclusion, granulomatous interstitial nephritis is a genuine extraintestinal manifestation of Crohn's disease, the treatment of which should include immunosuppressive agents.

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