Granulomatous interstitial nephritis and Crohn's disease

Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in...

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Autores principales: Timmermans, Sjoerd A.M.E.G., Christiaans, Maarten H.L., Abdul-Hamid, Myrurgia A., Stifft, Frank, Damoiseaux, Jan G.M.C., van Paassen, Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Kidney in Systemic Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957721/
https://www.ncbi.nlm.nih.gov/pubmed/27478596
http://dx.doi.org/10.1093/ckj/sfw041
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author Timmermans, Sjoerd A.M.E.G.
Christiaans, Maarten H.L.
Abdul-Hamid, Myrurgia A.
Stifft, Frank
Damoiseaux, Jan G.M.C.
van Paassen, Pieter
author_facet Timmermans, Sjoerd A.M.E.G.
Christiaans, Maarten H.L.
Abdul-Hamid, Myrurgia A.
Stifft, Frank
Damoiseaux, Jan G.M.C.
van Paassen, Pieter
author_sort Timmermans, Sjoerd A.M.E.G.
collection PubMed
description Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatment, renal function either improved or stabilized in both patients. In conclusion, granulomatous interstitial nephritis is a genuine extraintestinal manifestation of Crohn's disease, the treatment of which should include immunosuppressive agents.
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spelling pubmed-49577212016-07-29 Granulomatous interstitial nephritis and Crohn's disease Timmermans, Sjoerd A.M.E.G. Christiaans, Maarten H.L. Abdul-Hamid, Myrurgia A. Stifft, Frank Damoiseaux, Jan G.M.C. van Paassen, Pieter Clin Kidney J Kidney in Systemic Disease Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatment, renal function either improved or stabilized in both patients. In conclusion, granulomatous interstitial nephritis is a genuine extraintestinal manifestation of Crohn's disease, the treatment of which should include immunosuppressive agents. Oxford University Press 2016-08 2016-05-26 /pmc/articles/PMC4957721/ /pubmed/27478596 http://dx.doi.org/10.1093/ckj/sfw041 Text en © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Kidney in Systemic Disease
Timmermans, Sjoerd A.M.E.G.
Christiaans, Maarten H.L.
Abdul-Hamid, Myrurgia A.
Stifft, Frank
Damoiseaux, Jan G.M.C.
van Paassen, Pieter
Granulomatous interstitial nephritis and Crohn's disease
title Granulomatous interstitial nephritis and Crohn's disease
title_full Granulomatous interstitial nephritis and Crohn's disease
title_fullStr Granulomatous interstitial nephritis and Crohn's disease
title_full_unstemmed Granulomatous interstitial nephritis and Crohn's disease
title_short Granulomatous interstitial nephritis and Crohn's disease
title_sort granulomatous interstitial nephritis and crohn's disease
topic Kidney in Systemic Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957721/
https://www.ncbi.nlm.nih.gov/pubmed/27478596
http://dx.doi.org/10.1093/ckj/sfw041
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