Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity

Nonreplicating type I uracil auxotrophic mutants of Toxoplasma gondii possess a potent ability to activate therapeutic immunity to established solid tumors by reversing immune suppression in the tumor microenvironment. Here we engineered targeted deletions of parasite secreted effector proteins usin...

Descripción completa

Detalles Bibliográficos
Autores principales: Fox, Barbara A., Sanders, Kiah L., Rommereim, Leah M., Guevara, Rebekah B., Bzik, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957766/
https://www.ncbi.nlm.nih.gov/pubmed/27447180
http://dx.doi.org/10.1371/journal.pgen.1006189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957766/
https://www.ncbi.nlm.nih.gov/pubmed/27447180
http://dx.doi.org/10.1371/journal.pgen.1006189

Ejemplares similares