Cargando…

Abolishing HIV-1 infectivity using a polypurine tract-specific G-quadruplex-forming oligonucleotide

BACKGROUND: HIV is primarily transmitted by sexual intercourse and predominantly infects people in Third World countries. Here an important medical need is self-protection for women, particularly in societies where condoms are not widely accepted. Therefore, availability of antiviral microbicides ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Voges, Maike, Schneider, Carola, Sinn, Malte, Hartig, Jörg S., Reimer, Rudolph, Hauber, Joachim, Moelling, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957839/ https://www.ncbi.nlm.nih.gov/pubmed/27450669 http://dx.doi.org/10.1186/s12879-016-1713-x

Ejemplares similares

Targeting MYC Regulation with Polypurine Reverse Hoogsteen Oligonucleotides
por: Valiuska, Simonas, et al.
Publicado: (2022)

Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes
por: Solé, Anna, et al.
Publicado: (2017)

Targeting KRAS Regulation with PolyPurine Reverse Hoogsteen Oligonucleotides
por: Psaras, Alexandra Maria, et al.
Publicado: (2022)

Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase
por: Figiel, Małgorzata, et al.
Publicado: (2018)

Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents
por: Sun, Daekyu, et al.
Publicado: (2005)

Evaluation and Prediction of the HIV-1 Central Polypurine Tract Influence on Foamy Viral Vectors to Transduce Dividing and Growth-Arrested Cells
por: Shityakov, Sergey, et al.
Publicado: (2014)

INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay
por: Smith, Steven J., et al.
Publicado: (2021)

Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins
por: Aubets, Eva, et al.
Publicado: (2020)

G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents
por: Musumeci, Domenica, et al.
Publicado: (2015)

SiRNA-Induced Mutation in HIV-1 Polypurine Tract Region and Its Influence on Viral Fitness
por: Rausch, Jason W., et al.
Publicado: (2015)

Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands
por: Turner, Kevin B., et al.
Publicado: (2008)

Structure and Stability of a Dimeric G-Quadruplex Formed by Cyclic Oligonucleotides
por: Casals, Joan, et al.
Publicado: (2010)

Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA
por: Boutimah-Hamoudi, Fatima, et al.
Publicado: (2007)

Viral Reverse Transcriptases Show Selective High Affinity Binding to DNA-DNA Primer-Templates that Resemble the Polypurine Tract
por: Nair, Gauri R., et al.
Publicado: (2012)

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis
por: Betancor, Gilberto, et al.
Publicado: (2015)

How Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir
por: Das, Atze T., et al.
Publicado: (2018)

The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides
por: Saccà, Barbara, et al.
Publicado: (2005)

Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis
por: Rausch, Jason W., et al.
Publicado: (2007)

Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy
por: Acharya, Arpan, et al.
Publicado: (2020)

Investigation of a Quadruplex-Forming Repeat Sequence Highly Enriched in Xanthomonas and Nostoc sp.
por: Rehm, Charlotte, et al.
Publicado: (2015)

Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems
por: Bialek, Julia K., et al.
Publicado: (2016)

PolyPurine Reverse Hoogsteen Hairpins Work as RNA Species for Gene Silencing
por: Aubets, Eva, et al.
Publicado: (2021)

Predictable suppression of gene expression by 5′-UTR-based RNA quadruplexes
por: Halder, Kangkan, et al.
Publicado: (2009)

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells
por: Temime-Smaali, Nassima, et al.
Publicado: (2009)

Conformational changes in quadruplex oligonucleotide structures probed by Raman spectroscopy
por: Pagba, Cynthia V., et al.
Publicado: (2010)

Hole Migration in Telomere‐Based Oligonucleotide Anions and G‐Quadruplexes
por: Li, Wen, et al.
Publicado: (2019)

Spectroscopic Properties of Two 5′-(4-Dimethylamino)Azobenzene Conjugated G-Quadruplex Forming Oligonucleotides
por: Imperatore, Concetta, et al.
Publicado: (2020)

Reply to Das and Berkhout, “How Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir”
por: Malet, Isabelle, et al.
Publicado: (2018)

Correction of the aprt Gene Using Repair-Polypurine Reverse Hoogsteen Hairpins in Mammalian Cells
por: Félix, Alex J., et al.
Publicado: (2019)

Gene Correction of Point Mutations Using PolyPurine Reverse Hoogsteen Hairpins Technology
por: Félix, Alex J., et al.
Publicado: (2020)

Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivo
por: Czechowicz, Julia S., et al.
Publicado: (2018)

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues
por: Cadoni, Enrico, et al.
Publicado: (2021)

Polypurine Reverse-Hoogsteen Hairpins as a Tool for Exon Skipping at the Genomic Level in Mammalian Cells
por: Noé, Véronique, et al.
Publicado: (2021)

Abolish Outreach!
por: Beacham, James
Publicado: (2018)

"Abolishing" the Slums
Publicado: (1923)

Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells
por: Muench, David, et al.
Publicado: (2019)

Design and Properties of Ligand-Conjugated Guanine Oligonucleotides for Recovery of Mutated G-Quadruplexes
por: Takahashi, Shuntaro, et al.
Publicado: (2018)

Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes
por: Chowdhury, Souroprobho, et al.
Publicado: (2022)

A variant of guanidine-IV riboswitches exhibits evidence of a distinct ligand specificity
por: Lenkeit, Felina, et al.
Publicado: (2022)

Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches
por: Rouleau, Samuel G., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_0o1qm0qpf8lh4evdtl7f1iiv05