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Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization
[Image: see text] Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957849/ https://www.ncbi.nlm.nih.gov/pubmed/27333360 http://dx.doi.org/10.1021/jacs.6b04206 |
| _version_ | 1782444236677840896 |
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| author | Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai |
| author_facet | Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai |
| author_sort | Clarke, Christopher |
| collection | PubMed |
| description | [Image: see text] Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species. |
| format | Online Article Text |
| id | pubmed-4957849 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | American Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49578492016-07-25 Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai J Am Chem Soc [Image: see text] Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species. American Chemical Society 2016-06-22 2016-07-06 /pmc/articles/PMC4957849/ /pubmed/27333360 http://dx.doi.org/10.1021/jacs.6b04206 Text en Copyright © 2016 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| spellingShingle | Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization |
| title | Enantioselective
Nickel-Catalyzed anti-Carbometallative Cyclizations
of Alkynyl Electrophiles Enabled
by Reversible Alkenylnickel E/Z Isomerization |
| title_full | Enantioselective
Nickel-Catalyzed anti-Carbometallative Cyclizations
of Alkynyl Electrophiles Enabled
by Reversible Alkenylnickel E/Z Isomerization |
| title_fullStr | Enantioselective
Nickel-Catalyzed anti-Carbometallative Cyclizations
of Alkynyl Electrophiles Enabled
by Reversible Alkenylnickel E/Z Isomerization |
| title_full_unstemmed | Enantioselective
Nickel-Catalyzed anti-Carbometallative Cyclizations
of Alkynyl Electrophiles Enabled
by Reversible Alkenylnickel E/Z Isomerization |
| title_short | Enantioselective
Nickel-Catalyzed anti-Carbometallative Cyclizations
of Alkynyl Electrophiles Enabled
by Reversible Alkenylnickel E/Z Isomerization |
| title_sort | enantioselective
nickel-catalyzed anti-carbometallative cyclizations
of alkynyl electrophiles enabled
by reversible alkenylnickel e/z isomerization |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957849/ https://www.ncbi.nlm.nih.gov/pubmed/27333360 http://dx.doi.org/10.1021/jacs.6b04206 |
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