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Gut microbiota-host interactions and juvenile idiopathic arthritis

BACKGROUND: Juvenile idiopathic arthritis is the most common form of chronic arthritis in children. There is mounting evidence that the microbiota may influence the disease. MAIN BODY: Recent observations in several systemic inflammatory diseases including JIA have indicated that abnormalities in th...

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Autores principales: Arvonen, Miika, Berntson, Lillemor, Pokka, Tytti, Karttunen, Tuomo J, Vähäsalo, Paula, Stoll, Matthew L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957868/
https://www.ncbi.nlm.nih.gov/pubmed/27448997
http://dx.doi.org/10.1186/s12969-016-0104-6
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author Arvonen, Miika
Berntson, Lillemor
Pokka, Tytti
Karttunen, Tuomo J
Vähäsalo, Paula
Stoll, Matthew L
author_facet Arvonen, Miika
Berntson, Lillemor
Pokka, Tytti
Karttunen, Tuomo J
Vähäsalo, Paula
Stoll, Matthew L
author_sort Arvonen, Miika
collection PubMed
description BACKGROUND: Juvenile idiopathic arthritis is the most common form of chronic arthritis in children. There is mounting evidence that the microbiota may influence the disease. MAIN BODY: Recent observations in several systemic inflammatory diseases including JIA have indicated that abnormalities in the contents of the microbiota may be factors in disease pathogenesis, while other studies in turn have shown that environmental factors impacting the composition of the microbiota, such as delivery mode and early exposure to antibiotics, affect the risk of chronic inflammatory diseases including JIA. Microbial alterations may predispose to JIA through a variety of mechanisms, including impaired immunologic development, alterations in the balances of pro- versus anti-inflammatory bacteria, and low-grade mucosal inflammation. Additional confirmatory studies of microbiota aberrations and their risk factors are needed, as well as additional mechanistic studies linking these alterations to the disease itself. CONCLUSIONS: The microbiota may influence the risk of JIA and other systemic inflammatory conditions through a variety of mechanisms. Additional research is required to improve our understanding of the links between the microbiota and arthritis, and the treatment implications thereof.
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spelling pubmed-49578682016-07-23 Gut microbiota-host interactions and juvenile idiopathic arthritis Arvonen, Miika Berntson, Lillemor Pokka, Tytti Karttunen, Tuomo J Vähäsalo, Paula Stoll, Matthew L Pediatr Rheumatol Online J Review BACKGROUND: Juvenile idiopathic arthritis is the most common form of chronic arthritis in children. There is mounting evidence that the microbiota may influence the disease. MAIN BODY: Recent observations in several systemic inflammatory diseases including JIA have indicated that abnormalities in the contents of the microbiota may be factors in disease pathogenesis, while other studies in turn have shown that environmental factors impacting the composition of the microbiota, such as delivery mode and early exposure to antibiotics, affect the risk of chronic inflammatory diseases including JIA. Microbial alterations may predispose to JIA through a variety of mechanisms, including impaired immunologic development, alterations in the balances of pro- versus anti-inflammatory bacteria, and low-grade mucosal inflammation. Additional confirmatory studies of microbiota aberrations and their risk factors are needed, as well as additional mechanistic studies linking these alterations to the disease itself. CONCLUSIONS: The microbiota may influence the risk of JIA and other systemic inflammatory conditions through a variety of mechanisms. Additional research is required to improve our understanding of the links between the microbiota and arthritis, and the treatment implications thereof. BioMed Central 2016-07-22 /pmc/articles/PMC4957868/ /pubmed/27448997 http://dx.doi.org/10.1186/s12969-016-0104-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Arvonen, Miika
Berntson, Lillemor
Pokka, Tytti
Karttunen, Tuomo J
Vähäsalo, Paula
Stoll, Matthew L
Gut microbiota-host interactions and juvenile idiopathic arthritis
title Gut microbiota-host interactions and juvenile idiopathic arthritis
title_full Gut microbiota-host interactions and juvenile idiopathic arthritis
title_fullStr Gut microbiota-host interactions and juvenile idiopathic arthritis
title_full_unstemmed Gut microbiota-host interactions and juvenile idiopathic arthritis
title_short Gut microbiota-host interactions and juvenile idiopathic arthritis
title_sort gut microbiota-host interactions and juvenile idiopathic arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957868/
https://www.ncbi.nlm.nih.gov/pubmed/27448997
http://dx.doi.org/10.1186/s12969-016-0104-6
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