Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos

BACKGROUND: Adult hematopoietic stem cells (HSCs), the ideal system for regenerative research, were isolated at single cell levels decades ago, whereas studies on embryonic HSCs are much more difficult. METHODS: Zhou et al identified a new pre-HSC cell surface marker, CD201, by which they isolated p...

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Detalles Bibliográficos
Autores principales: Wang, Xiaochen, Gong, Yuemin, Ema, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957898/
https://www.ncbi.nlm.nih.gov/pubmed/27448408
http://dx.doi.org/10.1186/s13045-016-0289-7
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author Wang, Xiaochen
Gong, Yuemin
Ema, Hideo
author_facet Wang, Xiaochen
Gong, Yuemin
Ema, Hideo
author_sort Wang, Xiaochen
collection PubMed
description BACKGROUND: Adult hematopoietic stem cells (HSCs), the ideal system for regenerative research, were isolated at single cell levels decades ago, whereas studies on embryonic HSCs are much more difficult. METHODS: Zhou et al identified a new pre-HSC cell surface marker, CD201, by which they isolated pre-HSCs at single cell levels for further analyses. RESULTS: The novel expression pattern of HSC development is revealed, including the fundamental role of mammalian targets of rapamycin (mTOR) signaling pathway in HSCs emergence, and the repopulation potential of S/G2/M phase pre-HSCs. CONCLUSIONS: Deeper understandings of the cellular origin and developmental regulatory network of HSCs are essential to develop new strategies of generating HSCs in vitro for clinical application.
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spelling pubmed-49578982016-07-23 Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos Wang, Xiaochen Gong, Yuemin Ema, Hideo J Hematol Oncol Research Highlight BACKGROUND: Adult hematopoietic stem cells (HSCs), the ideal system for regenerative research, were isolated at single cell levels decades ago, whereas studies on embryonic HSCs are much more difficult. METHODS: Zhou et al identified a new pre-HSC cell surface marker, CD201, by which they isolated pre-HSCs at single cell levels for further analyses. RESULTS: The novel expression pattern of HSC development is revealed, including the fundamental role of mammalian targets of rapamycin (mTOR) signaling pathway in HSCs emergence, and the repopulation potential of S/G2/M phase pre-HSCs. CONCLUSIONS: Deeper understandings of the cellular origin and developmental regulatory network of HSCs are essential to develop new strategies of generating HSCs in vitro for clinical application. BioMed Central 2016-07-22 /pmc/articles/PMC4957898/ /pubmed/27448408 http://dx.doi.org/10.1186/s13045-016-0289-7 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Wang, Xiaochen
Gong, Yuemin
Ema, Hideo
Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
title Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
title_full Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
title_fullStr Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
title_full_unstemmed Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
title_short Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
title_sort chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957898/
https://www.ncbi.nlm.nih.gov/pubmed/27448408
http://dx.doi.org/10.1186/s13045-016-0289-7
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AT gongyuemin chasingtheprecursoroffunctionalhematopoieticstemcellsatthesinglecelllevelsinmouseembryos
AT emahideo chasingtheprecursoroffunctionalhematopoieticstemcellsatthesinglecelllevelsinmouseembryos

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