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Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study
BACKGROUND: Recruitment rates for cancer trials are low for racial/ethnic minorities. Little is known about factors influencing trial recruitment in Asian patients. Our aim is to examine the barriers and facilitators for participation in trials among multi-ethnic Asian women with breast cancer. METH...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957899/ https://www.ncbi.nlm.nih.gov/pubmed/27449505 http://dx.doi.org/10.1186/s12905-016-0319-1 |
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author | Lee, Guek Eng Ow, Mandy Lie, Desiree Dent, Rebecca |
author_facet | Lee, Guek Eng Ow, Mandy Lie, Desiree Dent, Rebecca |
author_sort | Lee, Guek Eng |
collection | PubMed |
description | BACKGROUND: Recruitment rates for cancer trials are low for racial/ethnic minorities. Little is known about factors influencing trial recruitment in Asian patients. Our aim is to examine the barriers and facilitators for participation in trials among multi-ethnic Asian women with breast cancer. METHODS: We recruited a convenience sample from consecutive women seen at the National Cancer Centre. Two experienced bilingual (English and Chinese) moderators conducted focus groups to theme saturation. The question guide incorporated open-ended questions soliciting opinions about trial participation and knowledge. Women were first asked if they were willing, unwilling, or still open to participate in future trials. Sessions were audiotaped and transcribed. Transcripts were independently coded for emergent themes. RESULTS: Sixteen of 103 women approached participated in five focus groups. Chinese, Malay, and Indian participants aged 29 to 69 represented different cancer stages. Five had no prior knowledge of trials. We identified three major themes comprising of 22 minor themes for barriers and facilitators. The major themes were: 1) patient-related, 2) trial-related, and 3) sociocultural factors. Women willing to join trials expressed themes representing facilitators (better test therapy, cost-effective profile, or trust in doctors and local healthcare systems). Women unwilling to participate expressed themes associated with barriers, while women still open to participation expressed themes representing both facilitators and barriers. Malay women were more likely to express themes related to ‘fatalism’ as a barrier. DISCUSSION/CONCLUSION: We found that facilitators and barriers to trial participation among Asian women were similar to those previously reported in Western women. Knowledge of trials is limited among women receiving breast cancer treatment. Unique sociocultural factors suggest that approaches customised to local and community beliefs are needed to improve trial participation in minority groups. |
format | Online Article Text |
id | pubmed-4957899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49578992016-07-23 Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study Lee, Guek Eng Ow, Mandy Lie, Desiree Dent, Rebecca BMC Womens Health Research Article BACKGROUND: Recruitment rates for cancer trials are low for racial/ethnic minorities. Little is known about factors influencing trial recruitment in Asian patients. Our aim is to examine the barriers and facilitators for participation in trials among multi-ethnic Asian women with breast cancer. METHODS: We recruited a convenience sample from consecutive women seen at the National Cancer Centre. Two experienced bilingual (English and Chinese) moderators conducted focus groups to theme saturation. The question guide incorporated open-ended questions soliciting opinions about trial participation and knowledge. Women were first asked if they were willing, unwilling, or still open to participate in future trials. Sessions were audiotaped and transcribed. Transcripts were independently coded for emergent themes. RESULTS: Sixteen of 103 women approached participated in five focus groups. Chinese, Malay, and Indian participants aged 29 to 69 represented different cancer stages. Five had no prior knowledge of trials. We identified three major themes comprising of 22 minor themes for barriers and facilitators. The major themes were: 1) patient-related, 2) trial-related, and 3) sociocultural factors. Women willing to join trials expressed themes representing facilitators (better test therapy, cost-effective profile, or trust in doctors and local healthcare systems). Women unwilling to participate expressed themes associated with barriers, while women still open to participation expressed themes representing both facilitators and barriers. Malay women were more likely to express themes related to ‘fatalism’ as a barrier. DISCUSSION/CONCLUSION: We found that facilitators and barriers to trial participation among Asian women were similar to those previously reported in Western women. Knowledge of trials is limited among women receiving breast cancer treatment. Unique sociocultural factors suggest that approaches customised to local and community beliefs are needed to improve trial participation in minority groups. BioMed Central 2016-07-22 /pmc/articles/PMC4957899/ /pubmed/27449505 http://dx.doi.org/10.1186/s12905-016-0319-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lee, Guek Eng Ow, Mandy Lie, Desiree Dent, Rebecca Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study |
title | Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study |
title_full | Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study |
title_fullStr | Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study |
title_full_unstemmed | Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study |
title_short | Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study |
title_sort | barriers and facilitators for clinical trial participation among diverse asian patients with breast cancer: a qualitative study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957899/ https://www.ncbi.nlm.nih.gov/pubmed/27449505 http://dx.doi.org/10.1186/s12905-016-0319-1 |
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