First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131

The bla(IMP-14) carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring bla(IMP-14) within a class 1 int...

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Detalles Bibliográficos
Autores principales: Stoesser, Nicole, Sheppard, Anna E., Peirano, Gisele, Sebra, Robert P., Lynch, Tarah, Anson, Luke W., Kasarskis, Andrew, Motyl, Mary R., Crook, Derrick W., Pitout, Johann D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Epidemiology and Surveillance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958194/
https://www.ncbi.nlm.nih.gov/pubmed/27246777
http://dx.doi.org/10.1128/AAC.00840-16
Descripción
Sumario:The bla(IMP-14) carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring bla(IMP-14) within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C(2) plasmid. The emergence of bla(IMP-14) in this context in the ST131 lineage is of potential clinical concern.

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