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First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131

The bla(IMP-14) carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring bla(IMP-14) within a class 1 int...

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Autores principales: Stoesser, Nicole, Sheppard, Anna E., Peirano, Gisele, Sebra, Robert P., Lynch, Tarah, Anson, Luke W., Kasarskis, Andrew, Motyl, Mary R., Crook, Derrick W., Pitout, Johann D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958194/
https://www.ncbi.nlm.nih.gov/pubmed/27246777
http://dx.doi.org/10.1128/AAC.00840-16
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author Stoesser, Nicole
Sheppard, Anna E.
Peirano, Gisele
Sebra, Robert P.
Lynch, Tarah
Anson, Luke W.
Kasarskis, Andrew
Motyl, Mary R.
Crook, Derrick W.
Pitout, Johann D.
author_facet Stoesser, Nicole
Sheppard, Anna E.
Peirano, Gisele
Sebra, Robert P.
Lynch, Tarah
Anson, Luke W.
Kasarskis, Andrew
Motyl, Mary R.
Crook, Derrick W.
Pitout, Johann D.
author_sort Stoesser, Nicole
collection PubMed
description The bla(IMP-14) carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring bla(IMP-14) within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C(2) plasmid. The emergence of bla(IMP-14) in this context in the ST131 lineage is of potential clinical concern.
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spelling pubmed-49581942016-07-26 First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131 Stoesser, Nicole Sheppard, Anna E. Peirano, Gisele Sebra, Robert P. Lynch, Tarah Anson, Luke W. Kasarskis, Andrew Motyl, Mary R. Crook, Derrick W. Pitout, Johann D. Antimicrob Agents Chemother Epidemiology and Surveillance The bla(IMP-14) carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring bla(IMP-14) within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C(2) plasmid. The emergence of bla(IMP-14) in this context in the ST131 lineage is of potential clinical concern. American Society for Microbiology 2016-07-22 /pmc/articles/PMC4958194/ /pubmed/27246777 http://dx.doi.org/10.1128/AAC.00840-16 Text en Copyright © 2016 Stoesser et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Epidemiology and Surveillance
Stoesser, Nicole
Sheppard, Anna E.
Peirano, Gisele
Sebra, Robert P.
Lynch, Tarah
Anson, Luke W.
Kasarskis, Andrew
Motyl, Mary R.
Crook, Derrick W.
Pitout, Johann D.
First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
title First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
title_full First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
title_fullStr First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
title_full_unstemmed First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
title_short First Report of bla(IMP-14) on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
title_sort first report of bla(imp-14) on a plasmid harboring multiple drug resistance genes in escherichia coli sequence type 131
topic Epidemiology and Surveillance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958194/
https://www.ncbi.nlm.nih.gov/pubmed/27246777
http://dx.doi.org/10.1128/AAC.00840-16
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