Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection

Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection. Using a mouse model of cryptococcal infection, we investigated the mec...

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Detalles Bibliográficos
Autores principales: Xu, Jintao, Eastman, Alison J., Flaczyk, Adam, Neal, Lori M., Zhao, Guolei, Carolan, Jacob, Malachowski, Antoni N., Stolberg, Valerie R., Yosri, Mohammed, Chensue, Stephen W., Curtis, Jeffrey L., Osterholzer, John J., Olszewski, Michal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958242/
https://www.ncbi.nlm.nih.gov/pubmed/27406560
http://dx.doi.org/10.1128/mBio.00510-16

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