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Transfer of DNA from Bacteria to Eukaryotes

Historically, the members of the Agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate DNA into the genomes of their eukaryotic hosts. Yet, increasing evidence suggests that this ability to genetically transform eukaryotic host cells might be mo...

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Detalles Bibliográficos
Autores principales: Lacroix, Benoît, Citovsky, Vitaly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958254/
https://www.ncbi.nlm.nih.gov/pubmed/27406565
http://dx.doi.org/10.1128/mBio.00863-16
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author Lacroix, Benoît
Citovsky, Vitaly
author_facet Lacroix, Benoît
Citovsky, Vitaly
author_sort Lacroix, Benoît
collection PubMed
description Historically, the members of the Agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate DNA into the genomes of their eukaryotic hosts. Yet, increasing evidence suggests that this ability to genetically transform eukaryotic host cells might be more widespread in the bacterial world. Indeed, analyses of accumulating genomic data reveal cases of horizontal gene transfer from bacteria to eukaryotes and suggest that it represents a significant force in adaptive evolution of eukaryotic species. Specifically, recent reports indicate that bacteria other than Agrobacterium, such as Bartonella henselae (a zoonotic pathogen), Rhizobium etli (a plant-symbiotic bacterium related to Agrobacterium), or even Escherichia coli, have the ability to genetically transform their host cells under laboratory conditions. This DNA transfer relies on type IV secretion systems (T4SSs), the molecular machines that transport macromolecules during conjugative plasmid transfer and also during transport of proteins and/or DNA to the eukaryotic recipient cells. In this review article, we explore the extent of possible transfer of genetic information from bacteria to eukaryotic cells as well as the evolutionary implications and potential applications of this transfer.
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spelling pubmed-49582542016-07-25 Transfer of DNA from Bacteria to Eukaryotes Lacroix, Benoît Citovsky, Vitaly mBio Minireview Historically, the members of the Agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate DNA into the genomes of their eukaryotic hosts. Yet, increasing evidence suggests that this ability to genetically transform eukaryotic host cells might be more widespread in the bacterial world. Indeed, analyses of accumulating genomic data reveal cases of horizontal gene transfer from bacteria to eukaryotes and suggest that it represents a significant force in adaptive evolution of eukaryotic species. Specifically, recent reports indicate that bacteria other than Agrobacterium, such as Bartonella henselae (a zoonotic pathogen), Rhizobium etli (a plant-symbiotic bacterium related to Agrobacterium), or even Escherichia coli, have the ability to genetically transform their host cells under laboratory conditions. This DNA transfer relies on type IV secretion systems (T4SSs), the molecular machines that transport macromolecules during conjugative plasmid transfer and also during transport of proteins and/or DNA to the eukaryotic recipient cells. In this review article, we explore the extent of possible transfer of genetic information from bacteria to eukaryotic cells as well as the evolutionary implications and potential applications of this transfer. American Society for Microbiology 2016-07-12 /pmc/articles/PMC4958254/ /pubmed/27406565 http://dx.doi.org/10.1128/mBio.00863-16 Text en Copyright © 2016 Lacroix and Citovsky. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Minireview
Lacroix, Benoît
Citovsky, Vitaly
Transfer of DNA from Bacteria to Eukaryotes
title Transfer of DNA from Bacteria to Eukaryotes
title_full Transfer of DNA from Bacteria to Eukaryotes
title_fullStr Transfer of DNA from Bacteria to Eukaryotes
title_full_unstemmed Transfer of DNA from Bacteria to Eukaryotes
title_short Transfer of DNA from Bacteria to Eukaryotes
title_sort transfer of dna from bacteria to eukaryotes
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958254/
https://www.ncbi.nlm.nih.gov/pubmed/27406565
http://dx.doi.org/10.1128/mBio.00863-16
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