Combined cisplatin and aurora inhibitor treatment increase neuroblastoma cell death but surviving cells overproduce BDNF

Drug-resistance to chemotherapics in aggressive neuroblastoma (NB) is characterized by enhanced cell survival mediated by TrkB and its ligand, brain-derived neurotrophic factor (BDNF); thus reduction in BDNF levels represent a promising strategy to overcome drug-resistance, but how chemotherapics re...

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Detalles Bibliográficos
Autores principales: Polacchini, Alessio, Albani, Clara, Baj, Gabriele, Colliva, Andrea, Carpinelli, Patrizia, Tongiorgi, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958269/
https://www.ncbi.nlm.nih.gov/pubmed/27256407
http://dx.doi.org/10.1242/bio.016725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958269/
https://www.ncbi.nlm.nih.gov/pubmed/27256407
http://dx.doi.org/10.1242/bio.016725

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