A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model

The low-density lipoprotein receptor (LDLR) plays a critical role in the liver for the clearance of plasma low-density lipoprotein (LDL). Its deficiency causes hypercholesterolemia in many models. To facilitate the usage of rats as animal models for the discovery of cholesterol-lowering drugs, we to...

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Detalles Bibliográficos
Autores principales: Wang, Hong Yu, Quan, Chao, Hu, Chunxiu, Xie, Bingxian, Du, Yinan, Chen, Liang, Yang, Wei, Yang, Liu, Chen, Qiaoli, Shen, Bin, Hu, Bian, Zheng, Zhihong, Zhu, Haibo, Huang, Xingxu, Xu, Guowang, Chen, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958281/
https://www.ncbi.nlm.nih.gov/pubmed/27378433
http://dx.doi.org/10.1242/bio.019802

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