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Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis

PURPOSE: The association between CD14 -159C/T polymorphism and the susceptibility to gastric cancer (GC) has been reported. However, the results were inconclusive. In the present study, a case–control study and a meta-analysis were performed to assess the possible association between -159C/T in the...

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Autores principales: Gong, Ai-Min, Li, Xin-Yuan, Xie, Yi-Qiang, Jia, Zhan-Dong, Li, Yuan-Xin, Zou, Yong-Yan, Xu, Chang-Qing, Wang, Zhen-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958350/
https://www.ncbi.nlm.nih.gov/pubmed/27486336
http://dx.doi.org/10.2147/OTT.S95807
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author Gong, Ai-Min
Li, Xin-Yuan
Xie, Yi-Qiang
Jia, Zhan-Dong
Li, Yuan-Xin
Zou, Yong-Yan
Xu, Chang-Qing
Wang, Zhen-Yu
author_facet Gong, Ai-Min
Li, Xin-Yuan
Xie, Yi-Qiang
Jia, Zhan-Dong
Li, Yuan-Xin
Zou, Yong-Yan
Xu, Chang-Qing
Wang, Zhen-Yu
author_sort Gong, Ai-Min
collection PubMed
description PURPOSE: The association between CD14 -159C/T polymorphism and the susceptibility to gastric cancer (GC) has been reported. However, the results were inconclusive. In the present study, a case–control study and a meta-analysis were performed to assess the possible association between -159C/T in the CD14 gene and GC risk. PATIENTS AND METHODS: Relevant studies were searched in several databases including PubMed, Web of Science, EMBASE, Chinese National Knowledge Infrastructure database, and Wanfang database (last search was performed on December 30, 2015). In addition, a case–control study involving 164 GC cases and 169 controls was also performed in the analysis. Statistical analysis was performed by the software Revman5.3. RESULTS: A total of ten published studies and the present case–control study involving 2,844 GC and 3,983 controls were included for the meta-analysis. The analysis result indicated that the T allele of CD14 -159C/T polymorphism did not confer risk for GC (in our study: [P=0.93]; in the meta-analysis: T vs 2N odds ratio =1.28 and 95% confidence interval (CI) =0.95–1.24, [P=0.24]). However, we found a significant association in the recessive model (in our study: TT vs TC+CC [P=0.04]; in the meta-analysis: TT vs TC+CC odds ratio =1.12 and 95% CI =1.01–1.26, [P=0.04]). Furthermore, a subgroup analysis by ethnicity showed that TT genotype was significantly associated with GC in Asian (odds ratio =1.17 and 95% CI =1.02–1.34, [P=0.02]) but not in Caucasian. CONCLUSION: Our results highlight the TT genotype of CD14 -159C/T as a genetic susceptibility factor for gastric cancer, particularly, in Asians and population-based controls.
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spelling pubmed-49583502016-08-02 Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis Gong, Ai-Min Li, Xin-Yuan Xie, Yi-Qiang Jia, Zhan-Dong Li, Yuan-Xin Zou, Yong-Yan Xu, Chang-Qing Wang, Zhen-Yu Onco Targets Ther Original Research PURPOSE: The association between CD14 -159C/T polymorphism and the susceptibility to gastric cancer (GC) has been reported. However, the results were inconclusive. In the present study, a case–control study and a meta-analysis were performed to assess the possible association between -159C/T in the CD14 gene and GC risk. PATIENTS AND METHODS: Relevant studies were searched in several databases including PubMed, Web of Science, EMBASE, Chinese National Knowledge Infrastructure database, and Wanfang database (last search was performed on December 30, 2015). In addition, a case–control study involving 164 GC cases and 169 controls was also performed in the analysis. Statistical analysis was performed by the software Revman5.3. RESULTS: A total of ten published studies and the present case–control study involving 2,844 GC and 3,983 controls were included for the meta-analysis. The analysis result indicated that the T allele of CD14 -159C/T polymorphism did not confer risk for GC (in our study: [P=0.93]; in the meta-analysis: T vs 2N odds ratio =1.28 and 95% confidence interval (CI) =0.95–1.24, [P=0.24]). However, we found a significant association in the recessive model (in our study: TT vs TC+CC [P=0.04]; in the meta-analysis: TT vs TC+CC odds ratio =1.12 and 95% CI =1.01–1.26, [P=0.04]). Furthermore, a subgroup analysis by ethnicity showed that TT genotype was significantly associated with GC in Asian (odds ratio =1.17 and 95% CI =1.02–1.34, [P=0.02]) but not in Caucasian. CONCLUSION: Our results highlight the TT genotype of CD14 -159C/T as a genetic susceptibility factor for gastric cancer, particularly, in Asians and population-based controls. Dove Medical Press 2016-07-18 /pmc/articles/PMC4958350/ /pubmed/27486336 http://dx.doi.org/10.2147/OTT.S95807 Text en © 2016 Gong et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Gong, Ai-Min
Li, Xin-Yuan
Xie, Yi-Qiang
Jia, Zhan-Dong
Li, Yuan-Xin
Zou, Yong-Yan
Xu, Chang-Qing
Wang, Zhen-Yu
Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis
title Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis
title_full Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis
title_fullStr Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis
title_full_unstemmed Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis
title_short Association between CD14 SNP -159 C/T and gastric cancer: an independent case–control study and an updated meta-analysis
title_sort association between cd14 snp -159 c/t and gastric cancer: an independent case–control study and an updated meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958350/
https://www.ncbi.nlm.nih.gov/pubmed/27486336
http://dx.doi.org/10.2147/OTT.S95807
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