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Colorectal cancer development and advances in screening
Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorect...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958365/ https://www.ncbi.nlm.nih.gov/pubmed/27486317 http://dx.doi.org/10.2147/CIA.S109285 |
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author | Simon, Karen |
author_facet | Simon, Karen |
author_sort | Simon, Karen |
collection | PubMed |
description | Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorectal cancer (CRC), which may lead to substantial decreases in the incidence of CRC. Despite the known benefits of early screening, CRC remains the second leading cause of cancer-related deaths in the United States. Hence, it is important for health care providers to have an understanding of the risk factors for CRC and various stages of disease development in order to recommend appropriate screening strategies. This article provides an overview of the histological/molecular changes that characterize the development of CRC. It describes the available CRC screening methods and their advantages and limitations and highlights the stages of CRC development in which each screening method is most effective. |
format | Online Article Text |
id | pubmed-4958365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49583652016-08-02 Colorectal cancer development and advances in screening Simon, Karen Clin Interv Aging Review Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorectal cancer (CRC), which may lead to substantial decreases in the incidence of CRC. Despite the known benefits of early screening, CRC remains the second leading cause of cancer-related deaths in the United States. Hence, it is important for health care providers to have an understanding of the risk factors for CRC and various stages of disease development in order to recommend appropriate screening strategies. This article provides an overview of the histological/molecular changes that characterize the development of CRC. It describes the available CRC screening methods and their advantages and limitations and highlights the stages of CRC development in which each screening method is most effective. Dove Medical Press 2016-07-19 /pmc/articles/PMC4958365/ /pubmed/27486317 http://dx.doi.org/10.2147/CIA.S109285 Text en © 2016 Simon. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Simon, Karen Colorectal cancer development and advances in screening |
title | Colorectal cancer development and advances in screening |
title_full | Colorectal cancer development and advances in screening |
title_fullStr | Colorectal cancer development and advances in screening |
title_full_unstemmed | Colorectal cancer development and advances in screening |
title_short | Colorectal cancer development and advances in screening |
title_sort | colorectal cancer development and advances in screening |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958365/ https://www.ncbi.nlm.nih.gov/pubmed/27486317 http://dx.doi.org/10.2147/CIA.S109285 |
work_keys_str_mv | AT simonkaren colorectalcancerdevelopmentandadvancesinscreening |