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Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique

Background. Acceptance of dual kidney transplantation (DKT) has proven difficult, due to surgical complexity and concerns regarding long-term outcomes. We herein present a standard technique for ipsilateral DKT and compare outcomes to single-kidney transplant (SKT) recipients. Methods. A retrospecti...

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Autores principales: Islam, Ana K., Knight, Richard J., Mayer, Wesley A., Hollander, Adam B., Patel, Samir, Teeter, Larry D., Graviss, Edward A., Saharia, Ashish, Podder, Hemangshu, Asham, Emad H., Gaber, A. Osama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958440/
https://www.ncbi.nlm.nih.gov/pubmed/27478630
http://dx.doi.org/10.1155/2016/2586761
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author Islam, Ana K.
Knight, Richard J.
Mayer, Wesley A.
Hollander, Adam B.
Patel, Samir
Teeter, Larry D.
Graviss, Edward A.
Saharia, Ashish
Podder, Hemangshu
Asham, Emad H.
Gaber, A. Osama
author_facet Islam, Ana K.
Knight, Richard J.
Mayer, Wesley A.
Hollander, Adam B.
Patel, Samir
Teeter, Larry D.
Graviss, Edward A.
Saharia, Ashish
Podder, Hemangshu
Asham, Emad H.
Gaber, A. Osama
author_sort Islam, Ana K.
collection PubMed
description Background. Acceptance of dual kidney transplantation (DKT) has proven difficult, due to surgical complexity and concerns regarding long-term outcomes. We herein present a standard technique for ipsilateral DKT and compare outcomes to single-kidney transplant (SKT) recipients. Methods. A retrospective single-center comparison of DKT and SKT performed between February 2007 and July 2013. Results. Of 516 deceased donor kidney transplants, 29 were DKT and 487 were SKT. Mean follow-up was 43 ± 67 months. DKT recipients were older and more likely than SKT recipients to receive an extended criteria graft (p < 0.001). For DKT versus SKT, the rates of delayed graft function (10.3 versus 9.2%) and acute rejection (20.7 versus 22.4%) were equivalent (p = ns). A higher than expected urologic complication rate in the DKT cohort (14 versus 2%, p < 0.01) was reduced through modification of the ureteral anastomosis. Graft survival was equivalent between DKT and SKT groups (p = ns) with actuarial 3-year DKT patient and graft survivals of 100% and 93%. At 3 years, the groups had similar renal function (p = ns). Conclusions. By utilizing extended criteria donor organs as DKT, the donor pool was enlarged while providing excellent patient and graft survival. The DKT urologic complication rate was reduced by modification of the ureteral anastomosis.
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spelling pubmed-49584402016-07-31 Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique Islam, Ana K. Knight, Richard J. Mayer, Wesley A. Hollander, Adam B. Patel, Samir Teeter, Larry D. Graviss, Edward A. Saharia, Ashish Podder, Hemangshu Asham, Emad H. Gaber, A. Osama J Transplant Research Article Background. Acceptance of dual kidney transplantation (DKT) has proven difficult, due to surgical complexity and concerns regarding long-term outcomes. We herein present a standard technique for ipsilateral DKT and compare outcomes to single-kidney transplant (SKT) recipients. Methods. A retrospective single-center comparison of DKT and SKT performed between February 2007 and July 2013. Results. Of 516 deceased donor kidney transplants, 29 were DKT and 487 were SKT. Mean follow-up was 43 ± 67 months. DKT recipients were older and more likely than SKT recipients to receive an extended criteria graft (p < 0.001). For DKT versus SKT, the rates of delayed graft function (10.3 versus 9.2%) and acute rejection (20.7 versus 22.4%) were equivalent (p = ns). A higher than expected urologic complication rate in the DKT cohort (14 versus 2%, p < 0.01) was reduced through modification of the ureteral anastomosis. Graft survival was equivalent between DKT and SKT groups (p = ns) with actuarial 3-year DKT patient and graft survivals of 100% and 93%. At 3 years, the groups had similar renal function (p = ns). Conclusions. By utilizing extended criteria donor organs as DKT, the donor pool was enlarged while providing excellent patient and graft survival. The DKT urologic complication rate was reduced by modification of the ureteral anastomosis. Hindawi Publishing Corporation 2016 2016-07-10 /pmc/articles/PMC4958440/ /pubmed/27478630 http://dx.doi.org/10.1155/2016/2586761 Text en Copyright © 2016 Ana K. Islam et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Islam, Ana K.
Knight, Richard J.
Mayer, Wesley A.
Hollander, Adam B.
Patel, Samir
Teeter, Larry D.
Graviss, Edward A.
Saharia, Ashish
Podder, Hemangshu
Asham, Emad H.
Gaber, A. Osama
Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
title Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
title_full Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
title_fullStr Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
title_full_unstemmed Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
title_short Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
title_sort intermediate-term outcomes of dual adult versus single-kidney transplantation: evolution of a surgical technique
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958440/
https://www.ncbi.nlm.nih.gov/pubmed/27478630
http://dx.doi.org/10.1155/2016/2586761
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