Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction. Post-translational modifications including phosphorylation, ubiquitination and truncation, are characteristic features of tau present i...

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Detalles Bibliográficos
Autores principales: Bondulich, Marie K., Guo, Tong, Meehan, Christopher, Manion, John, Rodriguez Martin, Teresa, Mitchell, Jacqueline C., Hortobagyi, Tibor, Yankova, Natalia, Stygelbout, Virginie, Brion, Jean-Pierre, Noble, Wendy, Hanger, Diane P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958900/
https://www.ncbi.nlm.nih.gov/pubmed/27297240
http://dx.doi.org/10.1093/brain/aww137

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