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Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats

Sestrin2 (Sesn2) exerts neuroprotective properties in some neurodegenerative diseases. However, the role of Sesn2 in stroke is unclear. The AMP-activated protein kinase/peroxisome proliferator-activated receptor γ coactivator-1α (AMPK/PGC-1α) pathway plays an important role in regulating mitochondri...

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Detalles Bibliográficos
Autores principales:	Li, Lingyu, Xiao, Lina, Hou, Yanghao, He, Qi, Zhu, Jin, Li, Yixin, Wu, Jingxian, Zhao, Jing, Yu, Shanshan, Zhao, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958997/ https://www.ncbi.nlm.nih.gov/pubmed/27453548 http://dx.doi.org/10.1038/srep30272

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