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Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014

Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to...

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Autores principales: Cao, Peihua, Wong, Chit-Ming, Chan, Kwok-Hung, Wang, Xiling, Chan, King-Pan, Peiris, Joseph Sriyal Malik, Poon, Leo Lit-Man, Yang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958999/
https://www.ncbi.nlm.nih.gov/pubmed/27453320
http://dx.doi.org/10.1038/srep30260
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author Cao, Peihua
Wong, Chit-Ming
Chan, Kwok-Hung
Wang, Xiling
Chan, King-Pan
Peiris, Joseph Sriyal Malik
Poon, Leo Lit-Man
Yang, Lin
author_facet Cao, Peihua
Wong, Chit-Ming
Chan, Kwok-Hung
Wang, Xiling
Chan, King-Pan
Peiris, Joseph Sriyal Malik
Poon, Leo Lit-Man
Yang, Lin
author_sort Cao, Peihua
collection PubMed
description Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses.
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spelling pubmed-49589992016-08-04 Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014 Cao, Peihua Wong, Chit-Ming Chan, Kwok-Hung Wang, Xiling Chan, King-Pan Peiris, Joseph Sriyal Malik Poon, Leo Lit-Man Yang, Lin Sci Rep Article Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses. Nature Publishing Group 2016-07-25 /pmc/articles/PMC4958999/ /pubmed/27453320 http://dx.doi.org/10.1038/srep30260 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cao, Peihua
Wong, Chit-Ming
Chan, Kwok-Hung
Wang, Xiling
Chan, King-Pan
Peiris, Joseph Sriyal Malik
Poon, Leo Lit-Man
Yang, Lin
Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
title Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
title_full Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
title_fullStr Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
title_full_unstemmed Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
title_short Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
title_sort age-specific genetic and antigenic variations of influenza a viruses in hong kong, 2013–2014
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958999/
https://www.ncbi.nlm.nih.gov/pubmed/27453320
http://dx.doi.org/10.1038/srep30260
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