ClC-3 Chloride Channel Proteins Regulate the Cell Cycle by Up-regulating cyclin D1-CDK4/6 through Suppressing p21/p27 Expression in Nasopharyngeal Carcinoma Cells

It was shown in this study that knockdown of ClC-3 expression by ClC-3 siRNA prevented the activation of hypotonicity-induced chloride currents, and arrested cells at the G0/G1 phase in nasopharyngeal carcinoma CNE-2Z cells. Reconstitution of ClC-3 expression with ClC-3 expression plasmids could res...

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Detalles Bibliográficos
Autores principales: Ye, Dong, Luo, Hai, Lai, Zhouyi, Zou, Lili, Zhu, Linyan, Mao, Jianwen, Jacob, Tim, Ye, Wencai, Wang, Liwei, Chen, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959003/
https://www.ncbi.nlm.nih.gov/pubmed/27451945
http://dx.doi.org/10.1038/srep30276

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